CUTTING FLUIDS AND THEIR EFFECTS ON THE SKIN OF MICE
Identifieur interne : 000C82 ( Istex/Checkpoint ); précédent : 000C81; suivant : 000C83CUTTING FLUIDS AND THEIR EFFECTS ON THE SKIN OF MICE
Auteurs : J Rgen R. Jepsen [Danemark] ; Stephan Stoyanov [Danemark] ; Mogens Unger [Danemark] ; J Rgen Clausen [Danemark] ; Hans Ewald Christensen [Danemark]Source :
- Acta Pathologica Microbiologica Scandinavica Section A Pathology [ 0365-4184 ] ; 1977-07.
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Abstract
Reports of skin malignancies due to occupational exposure have decreased since the introduction of solvent‐refining of mineral oil fraction in the manufacture of oil based cutting fluids. Commercial mineral oil based cutting fluids caused local and general pathological changes after repeated application to the skin of mice in the present study. Forty‐eight per cent of the mice exposed to oils showed severe dysplasia or malignancy of the skin on histological examination. The corresponding figure for the control group, where various additives were used was 8 per cent. The frequency of papillomas was also increased in the mice exposed to oils. The systemic lesions included focal necrosis of the liver, associated with amyloid deposition, as well as amyloidosis of the skin, spleen and kidneys. The substances responsible for these apparent carcinogenic properties of the complex mixtures may be polycyclic hydrocarbons; the latter are still present in the commercial products despite solvent refining; on the other hand the carcinogens may be the additives to the cutting oils the composition of which is generally a trade secret.
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DOI: 10.1111/j.1699-0463.1977.tb00465.x
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Commercial mineral oil based cutting fluids caused local and general pathological changes after repeated application to the skin of mice in the present study. Forty‐eight per cent of the mice exposed to oils showed severe dysplasia or malignancy of the skin on histological examination. The corresponding figure for the control group, where various additives were used was 8 per cent. The frequency of papillomas was also increased in the mice exposed to oils. The systemic lesions included focal necrosis of the liver, associated with amyloid deposition, as well as amyloidosis of the skin, spleen and kidneys. The substances responsible for these apparent carcinogenic properties of the complex mixtures may be polycyclic hydrocarbons; the latter are still present in the commercial products despite solvent refining; on the other hand the carcinogens may be the additives to the cutting oils the composition of which is generally a trade secret.</div></front></TEI><affiliations><list><country><li>Danemark</li></country></list><tree><country name="Danemark"><noRegion><name sortKey="Jepsen, J Rgen R" sort="Jepsen, J Rgen R" uniqKey="Jepsen J" first="J Rgen R." last="Jepsen">J Rgen R. Jepsen</name></noRegion><name sortKey="Christensen, Hans Ewald" sort="Christensen, Hans Ewald" uniqKey="Christensen H" first="Hans Ewald" last="Christensen">Hans Ewald Christensen</name><name sortKey="Christensen, Hans Ewald" sort="Christensen, Hans Ewald" uniqKey="Christensen H" first="Hans Ewald" last="Christensen">Hans Ewald Christensen</name><name sortKey="Clausen, J Rgen" sort="Clausen, J Rgen" uniqKey="Clausen J" first="J Rgen" last="Clausen">J Rgen Clausen</name><name sortKey="Clausen, J Rgen" sort="Clausen, J Rgen" uniqKey="Clausen J" first="J Rgen" last="Clausen">J Rgen Clausen</name><name sortKey="Jepsen, J Rgen R" sort="Jepsen, J Rgen R" uniqKey="Jepsen J" first="J Rgen R." last="Jepsen">J Rgen R. Jepsen</name><name sortKey="Stoyanov, Stephan" sort="Stoyanov, Stephan" uniqKey="Stoyanov S" first="Stephan" last="Stoyanov">Stephan Stoyanov</name><name sortKey="Stoyanov, Stephan" sort="Stoyanov, Stephan" uniqKey="Stoyanov S" first="Stephan" last="Stoyanov">Stephan Stoyanov</name><name sortKey="Unger, Mogens" sort="Unger, Mogens" uniqKey="Unger M" first="Mogens" last="Unger">Mogens Unger</name><name sortKey="Unger, Mogens" sort="Unger, Mogens" uniqKey="Unger M" first="Mogens" last="Unger">Mogens Unger</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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